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Updated: Jul 19, 2026
06:09
Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis
Published on: July 18, 2017
[Bilateral pyelonephritis and emphysematous cystitis: an exceptional association]
Hafed Ketata1, Bernard Debré, Michaël Peyromaure
1Service d'Urologie, Hôpital Cochin, Paris, France.
Summary
Emphysematous cystitis, a rare condition in diabetic patients, involves gas in the bladder and urinary tract. Prompt treatment with antibiotics and renal drainage is crucial due to its high mortality rate.
Area of Science:
- Nephrology
- Infectious Diseases
- Urology
Background:
- Emphysematous cystitis is a rare, severe infection of the urinary tract characterized by gas formation within the bladder wall.
- It predominantly affects diabetic patients and is often associated with specific bacterial pathogens.
- Prompt diagnosis and management are critical due to the potential for rapid progression and high morbidity.
Observation:
- The case involved a patient hospitalized with bilateral pyelonephritis and emphysematous cystitis.
- The patient required bilateral nephrostomy for renal drainage.
- Escherichia coli and Klebsiella pneumoniae were identified as the likely causative agents.
Findings:
- Treatment strategies include antibiotics and renal drainage (nephrostomy) or surgical intervention (nephrectomy).
- Despite aggressive treatment, the condition carries a poor prognosis.
- The reported mortality rate for emphysematous cystitis exceeds 50%.
Implications:
- This case highlights the severity of emphysematous cystitis, particularly in immunocompromised or diabetic individuals.
- Effective management necessitates a multidisciplinary approach involving urologists and infectious disease specialists.
- Further research into novel therapeutic strategies may improve outcomes for this life-threatening condition.
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