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New therapeutic modalities for cancer
1Department of Clinical Oncology, Royal Postgraduate Medical School, Hammersmith Hospital, London, England.
Acta Oncologica (Stockholm, Sweden)
|January 1, 1991
Summary
New biological therapies for cancer, including interferons and monoclonal antibodies, show promise. While current response rates are low, further research may lead to cures for metastatic solid tumors.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- Cancer therapy is evolving with new biological approaches.
- Understanding molecular mechanisms of malignancy is key.
- Interferons, interleukins, and other biological agents are being explored.
Purpose of the Study:
- To review novel biological strategies for cancer treatment.
- To highlight the potential of tailored biological manipulation.
- To assess the current status and future prospects of biological cancer therapy.
Main Methods:
- Review of scientific literature on biological cancer therapies.
- Analysis of key biological agents: interferons, interleukins, LAK-cells, TILs, TNF, CSFs, monoclonal antibodies, oncogenes.
- Discussion of molecular mechanisms driving malignancy and therapeutic targeting.
Main Results:
- Biological therapies offer diverse treatment permutations.
- Increased understanding of molecular malignancy allows for tailored treatments.
- Current clinical studies show modest response rates, similar to early chemotherapy.
Conclusions:
- Biological cancer therapy is a rapidly advancing field.
- Refinements in production, administration, and specificity are crucial.
- Potential exists for curing metastatic solid tumors with further development.