Related Experiment Video
Updated: Jul 19, 2026
05:35
Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance
Published on: June 6, 2025
Prostate specific antigen doubling time calculation: not as easy as 1, 2, 4
Timothy J Daskivich1, Meredith M Regan, William K Oh
1Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA.
The Journal of Urology
|October 31, 2006
Summary
Prostate specific antigen doubling time (PSADT) calculation methods vary widely, impacting accuracy. Consistent methodology is crucial for reliable prostate cancer prognosis and patient management.
Area of Science:
- Urology
- Oncology
- Medical Statistics
Background:
- Prostate specific antigen doubling time (PSADT) is a key biomarker for predicting prostate cancer progression and mortality.
- Current clinical practice often overlooks the significant impact of varied calculation methodologies on PSADT values.
Purpose of the Study:
- To critically review the diverse methods used for calculating PSADT in scientific literature.
- To highlight the necessity of methodological consistency for accurate PSADT interpretation in clinical settings.
Main Methods:
- A comprehensive literature review of studies utilizing PSADT as a prognostic indicator in prostate cancer was conducted via PubMed.
- Analysis included case examples from an institutional prostate cancer database of 4,651 patients.
Main Results:
- Significant inconsistencies exist in the methodology for calculating PSADT across published studies.
- Discrepancies in calculation methods can lead to substantial variations in PSADT, potentially causing misdiagnosis and incorrect treatment decisions.
- Key methodological parameters include calculation method, interval, data acquisition, and data analysis rules.
Conclusions:
- Methodological consistency in PSADT calculation is essential for accurate prognostic assessment and patient care.
- Clinicians and researchers must recognize how variations in methodology influence PSADT values for both clinical and research purposes.
