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Updated: Jul 19, 2026
08:08
Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
Published on: February 27, 2015
Molecular profiling techniques and bioinformatics in cancer research
A T Manning1, J T Garvin, R I Shahbazi
1Department of Surgery, Clinical Science Institute, University College Hospital, Galway, Ireland.
Summary
This review covers molecular profiling techniques in cancer research, detailing their limitations and the rise of bioinformatics. These high-throughput methods are crucial for understanding cancer genetics.
Area of Science:
- Genomics
- Molecular Biology
- Bioinformatics
Background:
- Cancer research increasingly relies on advanced molecular profiling.
- Understanding genetic alterations is key to cancer diagnosis and treatment.
Purpose of the Study:
- To review common molecular profiling techniques in cancer research.
- To examine the limitations of these technologies.
- To discuss the challenges posed by bioinformatics.
Main Methods:
- Literature search of the PubMed database.
- Examination of citations from identified articles.
Main Results:
- Description of DNA microarrays, comparative genomic hybridization, tissue microarrays, and digital differential display.
- Discussion of the limitations and contributions of these technologies to cancer research.
- Exploration of bioinformatics challenges associated with molecular profiling data.
Conclusions:
- High-throughput molecular profiling technologies, despite limitations, are advancing cancer genetics understanding.
- Bioinformatics has emerged as a vital and rapidly developing field due to these technologies.
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