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Updated: Jul 19, 2026
06:01
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Published on: July 6, 2017
Colorectal neoplasm and acromegaly.
Anil Bhansali1, Pinaki Dutta, Mohammad Hayat Bhat
1Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. anilbhansali_endocrine@rediffmail.com
Pituitary
|October 31, 2006
Summary
The risk of colorectal cancer in acromegaly patients is controversial. Despite earlier findings, two young patients without risk factors developed colorectal carcinoma, suggesting surveillance is needed.
Area of Science:
- Endocrinology and Oncology
Background:
- The association between acromegaly and colorectal carcinoma (CRC) risk is debated.
- Previous research suggested no increased CRC risk in Asian Indians with acromegaly, leading to the discontinuation of routine colonoscopies in this cohort.
Observation:
- Two young male patients, aged 30 and 35, were diagnosed with colorectal carcinoma.
- One patient developed CRC six years after acromegaly diagnosis, while the other was diagnosed concurrently.
- Neither patient had a family history of colonic neoplasm or other predisposing factors for CRC.
Findings:
- The occurrence of CRC in these young individuals without typical risk factors challenges previous assumptions.
- These cases suggest a potential link between acromegaly and the development of colorectal neoplasia, even in the absence of known risk factors.
Implications:
- Routine colonoscopy at the time of acromegaly diagnosis is recommended for all patients.
- Acromegaly patients should be under ongoing surveillance for colorectal neoplasia due to the observed risk.
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