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Updated: Jul 19, 2026

Enrichment of Bacterial Lipoproteins and Preparation of N-terminal Lipopeptides for Structural Determination by Mass Spectrometry
Published on: May 21, 2018
Synthesis of Staphylococcus aureus lipoteichoic acid derivatives for determining the minimal structural requirements
Ignacio Figueroa-Perez1, Andreas Stadelmaier, Susanne Deininger
1Fachbereich Chemie, Universität Konstanz, Fach M 725, D-78457 Konstanz, Germany.
Abstract:
For the investigation of the minimal structural requirements for cytokine induction, Staphylococcus aureus lipoteichoic acid derivatives with two, three, four, and five glycerophosphate backbone moieties, carrying each a d-alanyl residue, were needed. Based on two different glycerophosphate building blocks and 6b-O-phosphitylated gentiobiosyl diacylglycerol the desired target molecules (compounds 1-4) could be readily obtained and provided for biological studies.
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