Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelial function, mechanical stress and atherosclerosis.

Daniel Hayoz1, Lucia Mazzolai

  • 1Department of Medicine, Vascular Medicine, CHUV, Lausanne , Switzerland.

Advances in Cardiology
|November 1, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Downhill-walking exercise training in a patient with symptomatic peripheral artery disease: A case report.

Vascular medicine (London, England)·2026
Same author

Peripheral artery disease: time to recognize the systemic burden and reorganize care.

European journal of preventive cardiology·2026
Same author

[The Role of Nailfold Capillaroscopy in Raynaud's Phenomenon and Autoimmune Diseases].

Revue medicale suisse·2026
Same author

Sirolimus-Coated Balloon Angioplasty for Infrainguinal Artery Disease.

The New England journal of medicine·2026
Same author

Assessing preferred walking speed in patients with symptomatic chronic peripheral artery disease: Comparison of the 4-versus 10-meter walk test.

Vascular medicine (London, England)·2026
Same author

Structured exercise training and rehabilitation in patients with acute venous thromboembolism: a systematic review of randomized controlled trials.

European journal of preventive cardiology·2026
Same journal

Conclusion.

Advances in cardiology·2012
Same journal

Challenges in atrial fibrillation.

Advances in cardiology·2012
Same journal

Antiplatelet therapy in stroke prevention.

Advances in cardiology·2012
Same journal

Bleeding and the use of antiplatelet agents in the management of acute coronary syndromes and atrial fibrillation.

Advances in cardiology·2012
Same journal

Stents and antiplatelet therapy.

Advances in cardiology·2012
Same journal

Genetic considerations.

Advances in cardiology·2012
See all related articles

This review examines how mechanical stress and cardiovascular risk factors impact the early stages of atherosclerosis, a major cause of death. Understanding these combined effects is crucial for preventing cardiovascular disease.

Area of Science:

  • Cardiovascular Science
  • Pathophysiology
  • Vascular Biology

Background:

  • Atherosclerosis is a primary cause of global morbidity and mortality.
  • Established cardiovascular risk factors guide lifestyle modifications and drug development.
  • The endothelium is the initial site of vascular injury due to circulating factors and mechanical forces.

Purpose of the Study:

  • To review the combined impact of mechanical stress and cardiovascular risk factors on early atherosclerosis.
  • To highlight the endothelial response to these combined insults.

Main Methods:

  • Literature review focusing on endothelial function and atherosclerosis.
  • Analysis of studies investigating mechanical stress (e.g., shear stress, pressure) on the vasculature.

Related Experiment Videos

  • Integration of data on traditional cardiovascular risk factors and their interaction with mechanical forces.

    • Main Results:

    • Mechanical stress and cardiovascular risk factors synergistically promote endothelial dysfunction.
    • Early atherosclerotic changes are initiated by the combined effects on the endothelium.
    • The endothelium's vulnerability to mechanical forces is exacerbated by risk factors.

    Conclusions:

    • The interplay between mechanical stress and cardiovascular risk factors is critical in initiating atherosclerosis.
    • Targeting endothelial protection against combined insults may offer novel therapeutic strategies.
    • Further research is needed to elucidate the precise molecular mechanisms involved.