Related Experiment Video
Updated: Apr 3, 2026

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy
Published on: February 28, 2025
[The Role of Nailfold Capillaroscopy in Raynaud's Phenomenon and Autoimmune Diseases]
Ludovico Della Vedova1, Enrica Porceddu2, Lionel Arlettaz1,3
1Service d'immunologie et allergie, Centre hospitalier universitaire vaudois, 1011 Lausanne.
Abstract:
Connective tissue diseases are systemic autoimmune disorders for which diagnosis is often delayed owing to nonspecific early clinical manifestations. However, Raynaud's phenomenon is a common and early symptom that prompts etiological evaluation. In this context, nailfold capillaroscopy plays a pivotal role. It enables the detection of characteristic microvascular abnormalities, particularly the scleroderma pattern, which is strongly associated with systemic sclerosis and included in both classification and early diagnostic criteria. This review outlines the principles of capillaroscopy interpretation, its diagnostic and predictive value in systemic sclerosis, and its complementary role in other connective tissue diseases, even in the absence of acrosyndrome.
Related Concept Videos
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Assessment of the Cardiovascular System II: Inspection
Head and Neck
Cardiovascular System Abnormal Findings I: Inspection and Palpation
Abnormal findings observed during an inspection
Assessment of the Cardiovascular System III: Palpation
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

