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Updated: Jul 19, 2026
07:22
Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Basophils: a potential liaison between innate and adaptive immunity.
Booki Min1, Graham Le Gros, William E Paul
1Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA. minb@ccf.org
Summary
Innate immunity
Area of Science:
- Immunology
- Infectious Disease
Background:
- Innate immunity activation links to adaptive immune responses, particularly Th1 immunity.
- The role of innate immunity in Th2 adaptive immune responses remains unclear.
- Interleukin-4 (IL-4) production by innate cells is a potential link to Th2 immunity.
Purpose of the Study:
- Investigate the role of innate immune cells in initiating Th2 adaptive immunity.
- Identify innate cells responsible for IL-4 production during helminth infection.
- Understand basophil tissue homing and cytokine responses in Th2 immunity induction.
Main Methods:
- Studied the nematode infection model Nippostrongylus brasiliensis.
- Analyzed basophil accumulation in liver and spleen.
- Assessed IL-4 production by basophils.
Main Results:
- Observed significant basophil accumulation in the liver and spleen during infection.
- Demonstrated enhanced IL-4 production by these accumulated basophils.
- Identified basophils as key IL-4 producers in this Th2-inducing infection model.
Conclusions:
- Basophils are a crucial link between innate immunity and Th2 adaptive immune responses.
- Understanding basophil behavior is vital for elucidating in vivo Th2 immunity induction.
- This research highlights basophils as potential mediators of innate-adaptive links for Th2 immunity.
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