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Related Experiment Video

Updated: Jul 19, 2026

In Vivo Imaging and Tracking of Technetium-99m Labeled Bone Marrow Mesenchymal Stem Cells in Equine Tendinopathy

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[Thoracic soft tissue uptake on a bone scintigraphy. 2 cases].

A Biyi¹, A Doudouh, M Farik

¹Service de Médecine Nucléaire, Hôpital Militaire d'Instruction Mohammed-V, BP 6614, Rabat-Instituts, Rabat, Morocco. abiyi@caramail.com

Revue De Pneumologie Clinique

|November 1, 2006

Summary

Bone seeking radiopharmaceuticals can accumulate in chest soft tissues due to various reasons. This study details two cases of technetium-99m hydroxymethylene diphosphonate (99m-Tc-HMDP) uptake in the lung and diaphragm.

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Area of Science:

Nuclear Medicine
Radiopharmacology
Diagnostic Imaging

Background:

Bone-seeking radiopharmaceuticals, such as technetium-99m hydroxymethylene diphosphonate (99m-Tc-HMDP), are primarily used for skeletal imaging.
Unintended accumulation in non-skeletal tissues, particularly soft tissues of the chest, can complicate interpretations and indicate underlying pathology.

Observation:

Two distinct cases of abnormal 99m-Tc-HMDP uptake in the chest soft tissues are presented.
Case 1 involved uptake in the lung of a patient with localized amyloidosis.
Case 2 demonstrated uptake on diaphragmatic metastasis from a primitive neuroectodermal tumor (PNET).

Findings:

These cases highlight that 99m-Tc-HMDP uptake in the chest soft tissues is not exclusive to bone or metastatic bone disease.
Localized amyloidosis and metastatic PNET involving the diaphragm can manifest as abnormal radiopharmaceutical accumulation.
The mechanisms underlying such ectopic uptake require careful consideration during diagnostic imaging interpretation.

Implications:

Understanding these atypical uptake patterns is crucial for accurate diagnosis and avoiding misinterpretation in nuclear medicine imaging.
Further research into the specific mechanisms of radiopharmaceutical deposition in various soft tissue pathologies is warranted.
This knowledge can improve the diagnostic utility of bone-seeking agents in complex clinical scenarios.