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[Experimental study on the effect of tiangui gengnian capsule on the aged female rats ostepoprosis]
Bo Liu1, Bing-Xiang Yuan, Xiong Guo
1Department of Pharmacology, Xi'an Jiaotong University, Xi'an 710061, China.
Objective:
To study the therapeutic action of Seabuckthorn Fatty Acid on the aged female rats osteoporosis, and explore the corresponding mechanism related in hormone and cytokine.
Methods:
The change of bone density (BMD), biomechanics and bone morphology were measured and E2, TGF-beta1, IGF-1 level in plasma were determined respectively for the young female rats, aged female rats (Seabuckthorn Fatty Acid 0.72, 1.8, 4.5 g/kg, E2 0.02 g/kg) after they were administrated corresponding drugs for 45 days.
Results:
The bone density (BMD), bone biomechanics, bone morphology for female rats aged 22-months all decreased. The BMD, bone biomechanics, the number of bone trabeculas and cortical thickness in Seabuckthorn Fatty Acid treated groups (1.8 g/kg, 4.5 g/kg) were upgraded (P < 0.05). The TGF-beta1, IGF-1 level in plasma were increased, too (P < 0.05).
Conclusion:
Seabuckthorn Fatty Acid can meliorate bone metabolism in post-menopause and heighten the bone density. The adjustment mechanism may be based on the function of estrogen and cell cytokine.
