Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alternative splicing: therapeutic target and tool.

Mariano A Garcia-Blanco1

  • 1Department of Molecular Genetics and Microbiology, Center for RNA Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

Progress in Molecular and Subcellular Biology
|November 2, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Experimental validation of compound 3md, identified in silico, demonstrates antiviral effect on DENV2 by intervention in the replicative phase.

Virology·2026
Same author

Harnessing mRNA technology against <i>Fasciola hepatica</i>: Immunological insights from a fatty acid binding protein vaccine.

Frontiers in immunology·2025
Same author

Y-box binding proteins in immunity and RNA virus infection.

Microbiology and molecular biology reviews : MMBR·2025
Same author

Discovery of thiacyanine dyes as a new class of potent coronavirus inhibitors that suppress viral RNA synthesis.

The Journal of biological chemistry·2025
Same author

Host RNA-binding proteins and specialized viral RNA translation mechanisms: Potential antiviral targets.

Antiviral research·2025
Same author

Broad-spectrum antiviral ferruginol analog affects the viral proteins translation and actin remodeling during dengue virus infection.

Antiviral research·2025

Alternative splicing expands therapeutic targets by modifying the human proteome. Molecular therapies, including antisense oligonucleotides, offer new ways to target splicing for treating diseases.

Area of Science:

  • Molecular Biology
  • Genomics
  • Pharmacology

Background:

  • Alternative splicing significantly increases the coding potential of the human genome.
  • The resulting pharmacoproteome offers numerous targets for therapeutic intervention.
  • Splicing processes, both constitutive and regulated, are amenable to therapeutic targeting.

Purpose of the Study:

  • To review splicing as a therapeutic target, focusing on molecular approaches.
  • To discuss the application of antisense oligonucleotides in modulating splicing.
  • To evaluate RNA reprogramming methods for therapeutic potential.

Main Methods:

  • Review of current literature on splicing-targeted therapies.
  • Analysis of antisense oligonucleotide strategies (exon skipping, inhibition, stimulation).

Related Experiment Videos

  • Evaluation of trans-acting RNA recombination methods.

    • Main Results:

    • Antisense oligonucleotides can modulate alternative splicing by targeting specific exons.
    • RNA reprogramming techniques show promise for novel therapeutic strategies.
    • These molecular approaches hold potential for treating currently intractable diseases.

    Conclusions:

    • Splicing represents a versatile therapeutic target with expanding molecular strategies.
    • Antisense oligonucleotides and RNA reprogramming offer innovative treatment avenues.
    • Further research in these areas may lead to breakthroughs in treating complex genetic disorders.