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Neural crest cell plasticity. size matters.

Lisa L Sandell1, Paul A Trainor

  • 1Stowers Institute of Medical Research, 901 Volker Blvd., Kansas City, Missouri 64110, USA.

Advances in Experimental Medicine and Biology
|November 2, 2006
PubMed
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Neural crest cells guide vertebrate development, forming head and face structures. Their complex signaling pathways, influenced by surrounding tissues, are crucial for species-specific morphology and craniofacial development.

Area of Science:

  • Developmental Biology
  • Embryology
  • Cell Biology

Background:

  • Neural crest cells are vital for vertebrate development, forming diverse tissues including craniofacial structures.
  • Their development depends on intricate signaling interactions within the neuroepithelium and during migration.
  • Axial identity and patterning are influenced by Hox gene expression and conserved molecular pathways.

Purpose of the Study:

  • To elucidate the complex signaling networks governing neural crest cell development and patterning.
  • To understand how interactions with surrounding tissues shape neural crest-derived structures.
  • To highlight the plasticity and fixed aspects of neural crest cell fate determination.

Main Methods:

  • Analysis of signaling pathways including BMP, SHH, and FGF.

Related Experiment Videos

  • Investigating combinatorial Hox gene expression patterns.
  • Examining cellular interactions between neural crest and non-neural crest tissues.

    • Main Results:

    • Neural crest cell fate is regulated by a balance of intrinsic and extrinsic signals.
    • Hox gene expression dictates hindbrain neural crest axial identity.
    • Signaling pathways like BMP, SHH, and FGF are key regulators of neural crest patterning.

    Conclusions:

    • Neural crest cells act as a signaling cohort, directing axial patterns and species-specific craniofacial morphology.
    • Understanding endoderm, ectoderm, and mesoderm molecular determinants is critical for advancing craniofacial development research.
    • Conserved mechanisms govern neural crest patterning, but notable exceptions exist.