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Updated: Jul 9, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
Interplay of fidelity, binding strength, and structure in supramolecular polymers
Taiho Park1, Steven C Zimmerman
1Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.
Abstract:
In studies of a supramolecular network of polymers formed by self-association of UPy or UG recognition units displayed along a poly(butyl methacrylate) (PBMA) backbone, it was unexpectedly found that the more weakly dimerizing (Kdimer approximately 200 M-1) UG unit produced more assembly than did the very strongly dimerizing UPy unit (Kdimer = 2 x 107 M-1). Likewise, in examining supramolecular blends mediated by the heterocomplexation of DAN and UPy, which occurs upon the mixing of polystyrene containing the DAN unit (PS-DAN) and PBMA-UPy, increasing the mol % of UPy did not produce increased viscosity. 1H NMR showed that both observations can be explained by the intramolecular recognition of UPy. Structural studies show that the length of the chain linking the UPy unit to the backbone is critical, with longer linkers favoring intermolecular dimers. An interplay of linker chain length, polymer Mw, recognition unit mol %, and fidelity determines the extent of network growth.
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