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Related Experiment Videos

Multiple emulsions: an overview.

Azhar Yaqoob Khan1, Sushama Talegaonkar, Zeenat Iqbal

  • 1Department of Pharmaceutical Medicine, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India. azharykhan@yahoo.com

Current Drug Delivery
|November 2, 2006
PubMed
Summary

Multiple emulsions, systems with both oil-in-water and water-in-oil phases, offer versatile drug delivery. Stabilization techniques are key for applications like controlled release and oral delivery of sensitive drugs.

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Area of Science:

  • Pharmaceutical Sciences
  • Colloid and Surface Chemistry

Background:

  • Multiple emulsions feature simultaneous oil-in-water (o/w) and water-in-oil (w/o) droplets.
  • Stabilized by hydrophilic and lipophilic surfactants, their ratio is critical for stability.
  • Water-in-oil-in-water (w/o/w) emulsions are preferred for applications over oil-in-water-in-oil (o/w/o) types.

Purpose of the Study:

  • To review formulation and preparation techniques for multiple emulsions.
  • To discuss factors influencing multiple emulsion stability and stabilization strategies.
  • To highlight the potential applications of multiple emulsions in drug delivery and other fields.

Main Methods:

  • Review of existing literature on multiple emulsion formulation and characterization.
  • Analysis of factors affecting stability, including surfactant ratios and preparation methods.

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  • Exploration of in vitro and in vivo characteristics relevant to drug delivery.

    • Main Results:

    • Multiple emulsions, particularly w/o/w types, demonstrate significant potential as drug carriers.
    • Effective stabilization is achievable through careful control of surfactant ratios and preparation methods.
    • Favorable drug release profiles and in vivo behavior support their use in controlled and targeted delivery.

    Conclusions:

    • Multiple emulsions are promising for controlled/sustained drug delivery, taste masking, and bioavailability enhancement.
    • They are valuable for oral delivery of hydrophilic drugs like proteins and peptides.
    • Advancements in preparation and characterization will expand their use in pharmaceuticals and cosmetics.