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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Semisynthesis of isetexane diterpenoid analogues and their cytotoxic activity
Yutaka Aoyagi1, Yoshinao Takahashi, Haruhiko Fukaya
1School of Pharmacy, Tokyo University of Pharmacy & Life Science, Hachioji, Tokyo, Japan.
Chemical & Pharmaceutical Bulletin
|November 2, 2006
Abstract:
Isetexane diterpene analogues were semisynthesized from demethylsalvicanol isolated from Perovskia abrotanoides (Labiatae). The structure and cytotoxic activity relationships (SAR) of the natural parent diterpene, demethylsalvicanol, and its semisynthetic analogues were studied by using P388 murine leukemia cells.
