Related Experiment Video
Updated: Jul 19, 2026
06:30
Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
Published on: May 23, 2025
Ophthalmic cyclosporine use in ocular GVHD
Gary J Lelli1, David C Musch, Anurag Gupta
1Department of Ophthalmology and Visual Sciences, WK Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI 48105, USA.
Cornea
|November 2, 2006
Summary
Topical ophthalmic cyclosporine demonstrated safety and efficacy in treating dry eye symptoms associated with graft-versus-host disease (GVHD). The treatment improved ocular surface disease in most patients, offering a beneficial option for managing this complication.
Area of Science:
- Ophthalmology
- Immunology
- Transplantation Medicine
Background:
- Dry eye is a common complication of graft-versus-host disease (GVHD).
- Ocular surface disease in GVHD can significantly impact patient quality of life.
- Limited treatment options exist for severe dry eye secondary to GVHD.
Purpose of the Study:
- To assess the safety and efficacy of topical ophthalmic cyclosporine.
- To evaluate its use in patients experiencing dry eyes due to GVHD.
Main Methods:
- Retrospective review of patient records.
- Inclusion of patients with ocular GVHD treated with topical cyclosporine.
- Analysis of symptom improvement, corneal staining, and physician assessment.
Main Results:
- Dry eye symptoms improved in 62.5% of patients.
- Corneal fluorescein staining showed improvement in all treated eyes (P = 0.0039).
- Physician global impression was favorable in 75% of patients, with manageable side effects.
Conclusions:
- Topical ophthalmic cyclosporine appears safe and effective for ocular GVHD.
- It offers a potentially beneficial treatment for dry eye in this patient population.
- Consideration for patients with more severe dry eye manifestations is warranted.
Related Concept Videos
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
01:23Ophthalmic Drug Delivery Systems
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...