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Updated: Jul 19, 2026
18:48
Murine Renal Transplantation Procedure
Published on: July 10, 2009
Overview of a paediatric renal transplant programme.
M I McCulloch1, P Gajjar, C W N Spearman
1Department of Paediatric Nephrology, Red Cross War Memorial Children's Hospital, Rondebosch, Cape Town, South Africa.
Summary
Paediatric renal transplantation in developing countries can be successful, but long-term graft survival requires addressing challenges like infection and patient transition to adult care. Improving outcomes involves reducing nephrotoxic drugs and cardiovascular risks.
Area of Science:
- Nephrology
- Pediatric Surgery
- Transplantation Immunology
Background:
- Renal transplantation is the primary treatment for pediatric end-stage renal failure.
- Paediatric transplant programs in developing nations face organ scarcity and unique challenges.
Purpose of the Study:
- To evaluate the outcomes of a paediatric renal transplant program in a developing country.
- To identify challenges and areas for improvement in long-term graft and patient survival.
Main Methods:
- Retrospective review of 149 pediatric renal transplants (1968-2006), with focus on the last decade.
- Analysis of patient and graft survival rates.
- Review of drug-related issues and infections.
Main Results:
- 60% of transplants occurred in the last 10 years, showing satisfactory initial survival (8 years).
- Post-transplant infection (TB, CMV, EBV) is a major concern, surpassing rejection.
- Patient non-compliance after transfer to adult care is a significant issue.
Conclusions:
- Successful pediatric renal transplant programs are feasible in developing countries.
- Long-term success requires minimizing nephrotoxic drugs and cardiovascular risks.
- Facilitating smooth transition from pediatric to adult care is crucial for sustained outcomes.
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