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Related Experiment Videos

Ghrelin expression in human testis and serum testosterone level.

Tomomoto Ishikawa1, Hitoshi Fujioka, Takeshi Ishimura

  • 1Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan. iskwtmmt@med.kobe-u.ac.jp

Journal of Andrology
|November 3, 2006
PubMed
Summary

Ghrelin, a hormone linked to appetite, is found in human testes. Increased ghrelin in Leydig cells correlates with lower testosterone levels, suggesting a role in male reproductive health.

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Area of Science:

  • Endocrinology
  • Reproductive Biology
  • Molecular Biology

Background:

  • Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor (GHS-R).
  • Ghrelin primarily regulates growth hormone (GH) secretion and food intake.
  • Emerging evidence suggests ghrelin may influence testosterone (T) secretion.

Purpose of the Study:

  • To investigate the role and expression of ghrelin in human testicular function.
  • To determine the relationship between testicular ghrelin expression and hormone levels.

Main Methods:

  • Immunohistochemistry was used to detect ghrelin expression in testicular tissues from fertile volunteers and patients with infertility.
  • Serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T) were measured.

Related Experiment Videos

  • Ghrelin staining in Leydig cells was correlated with serum T concentrations and spermatogenesis (Johnsen score).

    • Main Results:

    • Ghrelin was detected in the interstitium and Leydig cells of human testes.
    • Ghrelin expression in Leydig cells showed an inverse correlation with serum testosterone levels (r=-.50; P<.001).
    • Testicular ghrelin expression was not directly related to the quality of spermatogenesis.

    Conclusions:

    • Steroidogenic dysfunction in the testes is associated with increased ghrelin expression.
    • Ghrelin may play a role in regulating testosterone production in human testes.