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Updated: Jul 19, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
Published on: June 8, 2014
[Action of glucocorticoid on bone-forming and bone-resorbing cells]
1Meikai University School of Dentistry, Division of Oral Anatomy.
Abstract:
During the early phase of glucocorticoid (GC)-induced osteoporosis (GIO), GC increases the expression of receptor activator of NF-kappaB ligand (RANKL) in bone-forming cells and suppresses the production of interferon-beta in osteoclast progenitors, resulting in stimulation of bone resorption. On the other hand, GC represses the proliferation, differentiation and functional activities of bone forming cells, and finally induces their apoptosis throughout GIO, consequently causing the decrease in bone formation. In addition, as the number of bone-forming cells decrease, the osteoblast-dependent osteoclast formation also declines.
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