Related Experiment Video
Updated: Jul 19, 2026

Mechanical Stimulation of Chondrocyte-agarose Hydrogels
Published on: October 27, 2012
[Cartilage formation and regeneration by mechanical stress]
1Osaka University Graduate School of Medicine, Department of Orthopaedic Surgery.
None:
Every cell in our body is subject to mechanical stress and responds to mechanical stimulation. Especially, tissues which function as a supportive tissue such as bone or cartilage utilize these stimulation during tissue formation and maintenance. Several lines of extensive studies have revealed the effects and mechanisms of mechanotransduction in cartilage or three dimensional engineered tissue. Furthermore, these biological responses to mechanical stimulation are thought to enhance cartilage formation or regeneration in vitro . Mechanical stimulation to a cultured tissue is thought to be a feasible strategy to develop a new cartilage therapy.
Related Concept Videos
Growth of Cartilage and Bone Tissue
Bone Formation by Endochondral Ossification
Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Remodeling
Development of the Limb Synovial Joints
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
Bone Remodeling and Repair
