Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clinically non-functioning pituitary adenoma.

Craig A Jaffe1

  • 1Division of Metabolism, Endocrinology and Diabetes, The University of Michigan, Michigan, USA. cjaffe@med.umich.edu

Pituitary
|November 4, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of preoperative thyroid hormone replacement with perioperative complications after major abdominal surgery.

American journal of surgery·2024
Same author

Role of endogenous ghrelin in growth hormone secretion, appetite regulation and metabolism.

Reviews in endocrine & metabolic disorders·2007
Same author

Multimodality imaging of malignant pheochromocytoma.

Clinical nuclear medicine·2006
Same author

The role of endogenous growth hormone-releasing hormone in acromegaly.

The Journal of clinical endocrinology and metabolism·2006
Same author

Endogenous circulating ghrelin does not mediate growth hormone rhythmicity or response to fasting.

The Journal of clinical endocrinology and metabolism·2005
Same author

Cryptococcal thyroiditis and hyperthyroidism.

Thyroid : official journal of the American Thyroid Association·2004
Same journal

Gauze swabbing technique for safe dissection of pituitary tumors.

Pituitary·2026
Same journal

Postoperative changes in circulating brain injury biomarkers in relation to long-term fatigue and cognitive outcomes after surgery for nonfunctioning pituitary adenomas.

Pituitary·2026
Same journal

Pituitary metastasis as an endocrine-neuro-ophthalmologic emergency: clinical red flags and outcomes from a contemporary tertiary-center series.

Pituitary·2026
Same journal

GH responsiveness to corticotropin-releasing hormone identifies corticotroph-like somatotroph adenomas in acromegaly.

Pituitary·2026
Same journal

Etomidate in severe hypercortisolism: early cortisol kinetics and clinical outcomes in a real-world cohort.

Pituitary·2026
Same journal

The effect of hypoprolactinemia on cardiometabolic effects of rosuvastatin in men: A matched Cohort Pilot Study.

Pituitary·2026
See all related articles

Non-functioning pituitary tumors, often incidental microadenomas, require treatment when macroadenomas cause mass effect or hypopituitarism. Transsphenoidal surgery is the primary treatment, improving symptoms and pituitary function, with radiation reserved for recurrent tumors.

Area of Science:

  • Endocrinology
  • Neurosurgery
  • Oncology

Background:

  • Non-functioning pituitary tumors are common, with microadenomas often asymptomatic.
  • Macroadenomas present with mass effect (e.g., visual field defects) and hypopituitarism, frequently impacting growth and gonadotropic function.
  • Immunocytochemistry reveals most are glycoprotein-producing, but few actively secrete hormones.

Purpose of the Study:

  • To outline the clinical presentation, diagnosis, and management of non-functioning pituitary tumors.
  • To discuss the efficacy of surgical and medical treatments.
  • To evaluate the role of radiation therapy and long-term surveillance.

Main Methods:

  • Review of clinical presentation, diagnostic findings (immunocytochemistry), and treatment outcomes.

Related Experiment Videos

  • Analysis of surgical (transsphenoidal resection) and medical therapies (dopamine/somatostatin agonists).
  • Assessment of radiation therapy's role and surveillance strategies.

    • Main Results:

    • Visual field defects and hypopituitarism (growth deficiency, hypogonadism) are common in symptomatic macroadenomas.
    • Transsphenoidal surgery is effective for mass effect and can restore pituitary function in some patients.
    • Tumor recurrence can occur in up to 50% at 10 years, but often remains asymptomatic.

    Conclusions:

    • Transsphenoidal surgery is the preferred initial treatment for symptomatic non-functioning pituitary macroadenomas.
    • Medical management has unreliable tumor response; radiation is reserved for significant recurrence.
    • Long-term surveillance with pituitary scans is crucial after treatment.