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Human body fluid proteome analysis.

Shen Hu1, Joseph A Loo, David T Wong

  • 1School of Dentistry, Division of Oral Biology and Medicine, Dental Research Institute, University of California, Los Angeles, CA 90095, USA. shenhu@ucla.edu

Proteomics
|November 4, 2006
PubMed
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This review covers advances in human body fluid proteome analysis for disease biomarker discovery. Proteomics technologies are essential for identifying and quantifying proteins in various body fluids to find new biomarkers.

Area of Science:

  • Proteomics
  • Biomarker Discovery
  • Human Physiology

Background:

  • Human body fluids contain a wealth of proteins relevant to health and disease.
  • Proteome analysis of these fluids offers a promising avenue for biomarker discovery.
  • Previous studies have explored various body fluids, but a comprehensive review of recent advances is needed.

Purpose of the Study:

  • To review recent advances in proteome analysis of diverse human body fluids.
  • To summarize current proteomics technologies for protein identification and quantification.
  • To discuss discovered biomarkers and future perspectives in human body fluid proteome (HBFP) analysis.

Main Methods:

  • Review of recent scientific literature on proteome analysis of human body fluids.

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  • Summarization of established and emerging proteomics technologies (e.g., mass spectrometry).
  • Analysis of reported human body fluid proteome (HBFP) studies and identified biomarkers.

    • Main Results:

    • Significant advancements in proteomics technologies enable global protein profiling of human body fluids.
    • Numerous potential biomarkers for various human diseases have been identified across different fluid types.
    • Key body fluids analyzed include plasma/serum, urine, cerebrospinal fluid, and saliva.

    Conclusions:

    • Human body fluid proteome (HBFP) analysis is a rapidly advancing field with high potential for disease biomarker discovery.
    • Continued technological innovation in proteomics will enhance the identification of clinically relevant biomarkers.
    • Further research and validation are crucial to translate HBFP findings into clinical applications.