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Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

The case for systemic therapy alone for prostate cancer.

Christopher Sweeney1

  • 1Indiana University School of Medicine, 535 Barnhill Drive No. 473, Indianapolis, IN 46202, USA. chsweene@iupui.edu

The Journal of Urology
|November 7, 2006
PubMed
Summary

Primary androgen deprivation therapy alone may be suitable for select prostate cancer patients. This approach can be used for localized or metastatic disease, depending on risk factors and life expectancy, to manage cancer and avoid overtreatment.

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Published on: March 6, 2018

Area of Science:

  • Oncology
  • Urology

Background:

  • Prostate cancer management involves various treatment modalities.
  • Androgen deprivation therapy (ADT) is a cornerstone treatment for advanced prostate cancer.

Purpose of the Study:

  • To review clinical scenarios for using primary androgen deprivation (AD) alone in organ-confined prostate cancer.
  • To guide therapeutic decision-making in prostate cancer management.

Main Methods:

  • Literature review using Medline and National Cancer Institute clinical trials databases.
  • Analysis of current and potential data for therapeutic decision-making.

Main Results:

  • Patient comorbidities and cancer histology can stratify risk for prostate cancer death.
  • Increased use of primary AD observed for both low and high-risk disease.
  • Reviewed outcome data for AD therapy alone in localized and metastatic prostate cancer.

Conclusions:

  • High-risk prostate cancer patients may benefit from systemic therapy alone for local and systemic disease control.
  • Patients with low-risk, indolent disease and limited life expectancy may consider deferred AD to avoid overtreatment.
  • ADT alone can be considered for organ-confined prostate cancer in specific clinical scenarios.