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Related Experiment Videos

Microscale bioprocess optimisation.

Martina Micheletti1, Gary J Lye

  • 1The Advanced Centre for Biochemical Engineering, Department of Biochemical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.

Current Opinion in Biotechnology
|November 7, 2006
PubMed
Summary
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Microscale processing accelerates drug development by analyzing bioprocesses at the microlitre scale. This approach reduces costs and enhances patient benefits through early, quantitative data for optimized manufacturing.

Area of Science:

  • Biotechnology and Bioprocessing
  • Pharmaceutical Sciences
  • Chemical Engineering

Background:

  • Traditional drug development is lengthy and costly.
  • Need for faster, more efficient bioprocess development.
  • Biopharmaceutical and chemical sectors seek improved methodologies.

Purpose of the Study:

  • To explore microscale processing for accelerated drug delivery.
  • To reduce drug development costs and enhance patient outcomes.
  • To inform bioprocess design and scale-up using early quantitative data.

Main Methods:

  • Utilizing microwell and microfluidic formats for microlitre-scale bioprocess analysis.
  • Studying individual bioprocess operations at the microscale.
  • Implementing automation for enhanced experimental throughput and parallel evaluations.

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Main Results:

  • Generation of quantitative bioprocess information at an early stage.
  • Demonstrated potential for speeding up translation to manufacturing scale.
  • Facilitation of parallel evaluation of biocatalysts and process options through automation.

Conclusions:

  • Microscale processing significantly accelerates new drug delivery.
  • Early quantitative data from microscale studies optimizes bioprocess design.
  • Automation enhances efficiency in evaluating process options for biopharmaceutical development.