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Updated: Jul 19, 2026

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
Dioscorea opposita reverses dexamethasone induced insulin resistance
Xiaoping Gao1, Bogang Li, Hanwen Jiang
1Institute of Materia Medica, Di-Ao Pharmaceutical Group, Chengdu 610041, China. gxplww2003@yahoo.com.cn
Abstract:
The effects of Dioscorea opposita (huai shan yao, HSY) on dexamethasone-induced insulin resistance were investigated in vitro and in vivo. D. opposita extract reduced significantly the blood insulin and glucose levels in dexamethasone-induced diabetic rats. In vitro, HSY significantly enhanced insulin-stimulated glucose uptake in 3T3-L1 adipocytes. Moreover, HSY increase the mRNA expression of GLUT4 glucose transporter in 3T3-L1 adipocytes. These data suggest that D. opposita has insulin sensitivity that is associated with the regulation of GLUT4 expression.
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