Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Detrusor quantitative morphometry in obstructed males and controls.

Argimiro Collado1, Emilio Batista, Antoni Gelabert-Más

  • 1Urology Service, Instituto Valenciano de Oncología, C/ Prof. Beltrán Báguena 8, 46009 Valencia, Spain. argimirocollado@usa.net

The Journal of Urology
|November 7, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-Term Functional Outcomes and Complications of Advance™/AdVance Xp™ Male Suburethral Slings in the Management of Post-Prostatectomy Incontinence: Multicentric Prospective Ten-Year Follow-Up Study.

Neurourology and urodynamics·2026
Same author

Validation of a 2-gene mRNA urine test for the detection of ≥GG2 prostate cancer in an opportunistic screening population.

The Prostate·2020
Same author

Ex-vivo confocal fluorescence microscopy for rapid evaluation of renal core biopsy.

Minerva urologica e nefrologica = The Italian journal of urology and nephrology·2019
Same author

Effectiveness and Complications of the AMS AdVance™ Male Sling System for the Treatment of Stress Urinary Incontinence: A Prospective Multicenter Study.

Urology·2018
Same author

Treatment Strategy for Newly Diagnosed T1 High-grade Bladder Urothelial Carcinoma: New Insights and Updated Recommendations.

European urology·2018
Same author

Functional follow-up after Advance<sup>®</sup> and Advance XP<sup>®</sup> male sling surgery: assessment of predictive factors.

World journal of urology·2018

Computer-assisted morphometry revealed increased detrusor muscle cell diameter and fibrosis in bladder outlet obstruction and acute urinary retention. Acute urinary retention showed more intrafascicular fibrosis, impacting functional recovery.

Area of Science:

  • Urology
  • Pathology
  • Medical Imaging

Background:

  • Bladder outlet obstruction (BOO) and acute urinary retention (AUR) significantly impact lower urinary tract function.
  • Understanding detrusor muscle changes is crucial for managing these conditions.
  • Computer-assisted morphometry offers a quantitative approach to assess tissue alterations.

Purpose of the Study:

  • To evaluate the utility of computer-assisted morphometry in measuring detrusor muscle cell diameter and the connective tissue-to-smooth muscle ratio.
  • To compare these morphometric parameters in patients with BOO, AUR, and a nonobstructed control group.

Main Methods:

  • A prospective study involving 62 male patients undergoing transurethral prostate resection.
  • Patients were categorized into BOO, AUR, and control groups.

Related Experiment Videos

  • Detrusor muscle cell diameter and connective tissue-to-smooth muscle ratio were measured using light microscopy and computer-assisted image analysis.

    • Main Results:

    • Patients with BOO and AUR exhibited significantly larger detrusor muscle cell diameter and increased fibrosis compared to controls.
    • AUR patients demonstrated greater intrafascicular fibrosis (higher connective tissue-to-smooth muscle ratio at 40x).
    • Detrusor muscle cell diameter correlated with symptom duration and functional recovery; fibrosis correlated with preoperative detrusor pressure and postoperative compliance.

    Conclusions:

    • Significant morphometric differences exist between control subjects and patients with BOO.
    • Increased detrusor muscle cell diameter and fibrosis are characteristic of BOO.
    • AUR is associated with more pronounced intrafascicular collagen deposition within the detrusor muscle.