Related Experiment Video
Updated: Jul 19, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
Published on: December 3, 2020
Cisapride decreasing orocecal transit time in patients with nonalcoholic steatohepatitis
1Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China. fxs888@3126.com
Background:
Altered small-intestine motility, lengthening of orocecal transit time (OCTT), and small-intestinal bacterial overgrowth (SIBO) have been detected in patients with nonalcoholic steatohepatitis (NASH). These changes might be related to the progressive course and poor prognosis of the disease. This study was undertaken to investigate the effect of 4-week treatment with cisapride on OCTT.
Methods:
Ten NASH patients without diabetes were included. Ten healthy individuals served as controls. OCTT was measured by lactulose breath test (LBT). Anti-endotoxin core antibodies (EndoCAb) IgG were also examined. The effect of cisapride (10 mg TID during 4 weeks) on LBT and serum EndoCAb IgG levels in NASH patients was investigated.
Results:
The NASH patients had more significantly prolonged OCTT (95 +/- 17 min) than the controls (59 +/- 18 min, P=0.00032). Cisapride administration decreased OCTT (from 95 +/- 17 min to 83 +/- 19 min, P=0.037), basal breathed H2 (from 9.87 +/- 1.60 ppm to 8.61 +/- 1.63 ppm, P=0.046) and EndoCAb IgG titers (from 5.24 +/- 0.68 GMU/ml to 4.20 +/- 0.72 GMU/ml, P=0.013) in NASH patients.
Conclusions:
The present data suggest the existence of deranged intestinal motility and endotoxemia in NASH patients. Cisapride administration during 4 weeks possibly restore intestinal motility and ameliorate endotoxemia in NASH patients.
Related Concept Videos
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
Drugs for Treatment of Constipation-Predominant IBS
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
Adsorbents...
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
