[Evaluation of fetal antigenic stimulation in physiological and complicated pregnancy]

Fetal hemoglobin and trophoblastic beta 1-globulin levels have been determined in women with normal and complicated pregnancy in order to evaluate the rates of fetal antigenic stimulation. It was demonstrated that trophoblastic beta 1-globulin may not exactly represent fetal antigenic structures, but it is a marker of functional feto-placental activity. An elevated percentage of HbF in blood in threatened+ abortion and early toxemia of pregnancy confirmed feasibility of using it as an indirect marker of fetal antigenic stimulation and permeability of the fetoplacental barrier.