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Increased plasma level of endothelin with vasoconstriction after dextran infusion
A Otsuka1, H Mikami, T Tsunetoshi
1Department of Geriatric Medicine, Osaka University Medical School, Japan.
Biochemistry International
|October 1, 1990
Summary
Volume expansion with dextran caused vasoconstriction and elevated blood pressure. While plasma endothelin levels changed, they did not directly correlate with blood pressure changes, suggesting its role requires further investigation.
Area of Science:
- Physiology
- Cardiovascular Research
- Pharmacology
Background:
- Previous research indicated that dextran-induced volume expansion leads to blood pressure elevation via vasoconstriction.
- The role of endogenous endothelin in mediating this post-infusion vasoconstriction remained unclear.
Purpose of the Study:
- To investigate the potential contribution of endogenous endothelin to dextran-induced vasoconstriction and blood pressure elevation.
Main Methods:
- Plasma endothelin levels were measured at baseline, immediately after dextran infusion, and 3 hours post-infusion.
- Blood pressure and total peripheral resistance were monitored to assess hemodynamic changes.
Main Results:
- Plasma endothelin levels decreased immediately post-dextran administration (1.5 ± 0.3 to 1.1 ± 0.2 pg/ml, P < 0.05).
- A significant increase in plasma endothelin was observed 3 hours after dextran infusion (2.1 ± 0.3 pg/ml, P < 0.05).
- Changes in plasma endothelin levels did not show a significant correlation with blood pressure or total peripheral resistance.
Conclusions:
- Dextran-induced vasoconstriction is associated with an increase in plasma endothelin levels.
- The direct causative role of endothelin in the observed vasoconstriction and blood pressure elevation requires further investigation.