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Updated: Jul 19, 2026
08:13
Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
Published on: January 7, 2018
[Glucose intolerance: postprandial hyper glucose, risk factor for diabetic macroangiopathy]
Yasuhiro Igarashi1, Ryuzo Kawamori
1Department of Medicine, Juntendo University.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|November 8, 2006
Summary
Simply improving glucose control is insufficient for preventing diabetes macroangiopathy. Addressing the underlying causes of postprandial hyperglycemia, such as insulin resistance, is key to reducing cardiovascular disease risk.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Cardiovascular Research
Context:
- Major studies indicate that glycemic control alone does not prevent diabetes macroangiopathy.
- Postprandial hyperglycemia is increasingly recognized as a significant risk factor for macrovascular complications.
- Impaired glucose tolerance (IGT) is a known precursor to cardiovascular disease.
Purpose:
- To investigate the pathophysiology underlying postprandial hyperglycemia as a risk factor for macroangiopathy.
- To identify and evaluate strategies for preventing postprandial hyperglycemia and its associated risks.
Summary:
- Macroangiopathy risk is linked to the pathophysiology causing postprandial hyperglycemia, specifically reduced insulin sensitivity and/or altered insulin secretion.
- Three strategies target postprandial hyperglycemia: enhancing hepatic insulin sensitivity, delaying portal glucose absorption, and restoring rapid insulin release.
- Each of these targeted strategies has demonstrated potential in reducing the risk of diabetes macroangiopathy.
Impact:
- This research highlights novel therapeutic targets beyond simple glucose lowering for managing diabetes complications.
- Understanding the pathophysiology of postprandial hyperglycemia can lead to more effective cardiovascular risk reduction strategies in diabetic patients.
- The findings support personalized interventions based on individual pathophysiological profiles to prevent diabetes-related macrovascular disease.
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