Related Experiment Video
Updated: Jul 19, 2026
Adult and Pediatric Porcine Model of Acute Volume Overload
Published on: January 12, 2024
Pressure-suit combined with pelvic stop-flow: a feasibility study in a bovine model
S Bonvalot1, M Bonnay, L Drouard-Troalen
1Department of Surgery, Institut Gustave Roussy, 94805 Villejuif, France. bonvalot@igr.fr
Background:
Isolated pelvic perfusion exposes tissue to high drug doses and may benefit patients with advanced malignancy. However, leakage is a limit to this technique.
Aims:
The aim of the study is to increase the perfusion ratio between local and systemic compartments on isolated pelvic perfusion. We hypothesised that an inflated pressure-suit placed above the level of aortic and caval stop flow could decrease leakage from the regional to the systemic blood compartment in a bovine model.
Method:
As the size of the pressure-suit was adapted for use in humans, we performed our experimental study on 6 calves which are big enough to fit into the suit. We used an inflated pressure-suit placed at low (40mmHg) and high pressures (125mmHg) above the level of aortic and caval stop-flow. A pharmacokinetic study with cisplatinum was performed in both compartments.
Results:
After injection of the drug, the mean ratio of drug concentration in the locoregional/systemic compartment was 43.1. After 30min, this mean ratio was 4 and 9.7 for a pressure-suit pressure of 40mmHg and 125mmHg, respectively. At pressure-suit pressures of 40mmHg and 125mmHg, pelvic perfusion achieved pelvic/systemic exposure ratios of 5.9 and 14.9 at 30min, respectively. Leakage at 30min was higher when the pressure-suit was inflated at low pressure (40mmHg, mean 18%). When the pressure-suit was inflated at high pressure, leakage was lower (125mmHg, mean 7%).
Conclusions:
The pressure-suit increased the perfusion ratio between pelvic and systemic compartments in a bovine model.