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Cancer-Critical Genes I: Proto-oncogenes

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Cancer-Critical Genes I: Proto-oncogenes

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Cancer

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

Cancers Originate from Somatic Mutations in a Single Cell

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

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Related Experiment Video

Updated: Jul 19, 2026

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

Published on: October 11, 2019

CancerGenes: a gene selection resource for cancer genome projects.

Maureen E Higgins¹, Martine Claremont, John E Major

¹Computational Biology Center Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, No. 460 New York, NY 10021, USA.

Nucleic Acids Research

|November 8, 2006

Summary

The CancerGenes resource aids researchers in identifying and prioritizing genes crucial for cancer research. It integrates expert-curated lists with public database information, simplifying the study of genetic variations in cancer.

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Last Updated: Jul 19, 2026

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

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Published on: October 11, 2019

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Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing

Published on: October 18, 2013

Area of Science:

Genomics
Cancer Biology
Bioinformatics

Background:

The Human Genome Project provides a framework for mapping genetic variations and their association with disease.
Germ-line variations and somatic mutations are critical in cancer development, risk, prognosis, and therapy response.
The Cancer Genome Atlas initiative aims to understand somatic mutations in cancer progression.

Purpose of the Study:

To develop the CancerGenes resource for simplifying gene selection and prioritization in large cancer research projects.
To integrate expert-annotated gene lists with data from public databases.

Main Methods:

Combined expert-curated gene lists with information from key public databases.
Annotated each gene with comprehensive details including functional description, genomic location, and links to external resources.
Developed a user-friendly interface for searching, sorting, and intersecting gene lists.
Enabled results viewing via web browser or dynamic download as a spreadsheet.

Main Results:

The CancerGenes resource provides a centralized platform for accessing annotated gene information relevant to cancer.
Facilitated efficient gene selection and prioritization for collaborative cancer genome studies.
Offered detailed annotations including gene names, functional descriptions, genomic data, and links to relevant databases and genome browsers.

Conclusions:

CancerGenes simplifies the complex process of gene selection and prioritization in large-scale cancer research.
This resource supports collaborative projects by providing integrated and accessible gene information.
The tool enhances the study of genetic variations and their role in cancer development and progression.