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Updated: Jul 19, 2026
08:51
Evaluation of Mammary Gland Development and Function in Mouse Models
Published on: July 21, 2011
Pubertal mammary gland development: insights from mouse models.
Jillian Howlin1, Jean McBryan, Finian Martin
1UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland, and Department of Laboratory Medicine, Malmo University Hospital, Sweden.
Journal of Mammary Gland Biology and Neoplasia
|November 8, 2006
Summary
Pubertal mammary gland development transforms a rudimentary structure into a complex ductal network. Gene-manipulated mouse models reveal key regulatory mechanisms controlling this rapid, hormonally-driven process.
Area of Science:
- Developmental Biology
- Endocrinology
- Genetics
Background:
- The mammary gland undergoes significant development during puberty, transitioning from a rudimentary structure to a branched ductal network.
- This complex process involves coordinated growth, proliferation, migration, branching, and apoptosis, all tightly regulated.
- Hormonal control is crucial, linking mammary gland development with overall reproductive maturation.
Purpose of the Study:
- To review findings from gene-manipulated mouse models of mammary gland development.
- To document common pubertal mammary gland phenotypes observed in these models.
- To summarize the contribution of these models to understanding pubertal mammary gland development.
Main Methods:
- Review of published literature on gene-manipulated mammary mouse models.
- Documentation of observed pubertal mammary gland phenotypes.
- Analysis of insights gained into regulatory mechanisms.
Main Results:
- Gene manipulation in mouse models has identified numerous pubertal mammary gland phenotypes.
- These models provide significant insights into the regulatory mechanisms governing pubertal development.
- A wide range of gene-manipulated models contribute to understanding this developmental period.
Conclusions:
- Gene-manipulated mouse models are invaluable tools for dissecting pubertal mammary gland development.
- Understanding these regulatory mechanisms is essential for comprehending normal gland formation.
- Further research using these models will continue to elucidate the complexities of mammary gland development.
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