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Protein kinases, their function and implication in cancer and other diseases
I Shchemelinin1, L Sefc, E Necas
1Institute of Pathological Physiology and Centre of Experimental Haematology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic. ishch@lfl.cuni.cz
Folia Biologica
|November 9, 2006
Summary
Protein kinases are crucial enzymes regulating cell functions. Dysregulation of these protein kinases can lead to diseases, making them key targets for therapeutic interventions.
Area of Science:
- Biochemistry
- Molecular Biology
- Cell Biology
Background:
- Protein phosphorylation is a key cellular regulatory mechanism.
- Protein kinases, including tyrosine and serine-threonine types, drive phosphorylation.
- Human protein kinase systems are complex and susceptible to functional alterations.
Purpose of the Study:
- To highlight the critical role of protein kinases in cellular processes.
- To underscore the involvement of protein kinases in human pathologies, particularly malignancies.
- To identify protein kinases as significant therapeutic targets.
Main Methods:
- Review of existing literature on protein kinase function and dysregulation.
- Analysis of the role of protein kinases in various cellular processes.
- Examination of the link between protein kinase alterations and disease development.
Main Results:
- Protein kinase activity is essential for cell division, metabolism, survival, and apoptosis.
- Altered protein kinase function is implicated in numerous diseases, especially cancers.
- Specific examples include chronic myelogenous leukaemia and gastrointestinal stromal tumours.
Conclusions:
- Protein kinases are vital effectors in human pathology.
- The intricate nature of protein kinase networks contributes to disease pathogenesis.
- Targeting protein kinases offers promising therapeutic strategies for various disorders.
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