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Updated: Jul 19, 2026
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
Nanoparticles for two-photon photodynamic therapy in living cells
De Gao1, Rodney R Agayan, Hao Xu
1Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA.
Abstract:
We describe here a nontoxic two-photon photodynamic nanoparticle platform and its cellular application. We demonstrate that the dye's potential toxicity can be circumvented by its permanent encapsulation into a biocompatible nanoparticle polymer matrix; this was examined by dye leaching experiments and confirmed by cell uptake experiments. Infrared two-photon nanoplatform phototoxicity was demonstrated for rat C6 glioma cells, while the controls showed no dark toxicity for these living cells.
