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Primary angiosarcoma of the bladder.

Raja R Seethala1, Jose A Gomez, Funda Vakar-Lopez

  • 1Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pa 15217, USA. seethalarr@upmc.edu

Archives of Pathology & Laboratory Medicine
|November 9, 2006
PubMed
Summary
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Primary bladder angiosarcomas are rare tumors in older men, often presenting as advanced, hemorrhagic masses. Despite their appearance, these angiosarcomas may have a better prognosis than previously understood.

Area of Science:

  • Urologic Oncology
  • Vascular Tumors
  • Pathology

Background:

  • Primary bladder angiosarcomas are exceptionally rare neoplasms.
  • Their clinical presentation and pathological characteristics are not well-documented.

Purpose of the Study:

  • To delineate the clinical features of primary bladder angiosarcomas.
  • To characterize the pathological spectrum of these rare tumors.

Main Methods:

  • Systematic literature review using MEDLINE and bibliographic searches.
  • Inclusion of cases from pathology archives.
  • Analysis of 9 confirmed primary bladder angiosarcomas, excluding secondary involvement.

Main Results:

  • Mean patient age was 64.2 years, with a male predominance (8:1 ratio).

Related Experiment Videos

  • Common presentation included hematuria and gross, hemorrhagic masses.
  • Histological findings varied, including classic and variant patterns.
  • Survival data indicated a potentially better prognosis than anticipated, with most patients alive at follow-up.

    • Conclusions:

    • Primary bladder angiosarcomas are rare, typically affecting middle-aged to elderly men.
    • These tumors often present as locally advanced disease with diverse histological features.
    • The prognosis for primary bladder angiosarcomas may be more favorable than previously reported.