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Improved Lipofuscin Models and Quantification of Outer Segment Phagocytosis Capacity in Highly Polarized Human Retinal Pigment Epithelial Cultures
Published on: April 14, 2023
Lipofuscin-like fluorophores originated from malondialdehyde
1Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan. uchidak@agr.nagoya-u.ac.jp
Free Radical Research
|November 9, 2006
Abstract:
The accumulation of fluorescent age pigment or lipofuscin is a frequently observed age-associated cellular alteration in a variety of post-mitotic cells of many species. These pigments are observed within granules composed, in part, of damaged protein and lipid. In the present mini-review, I provide a comprehensive summary of fluorescent adducts originated from malondialdehyde (MDA).
