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Antigens Involved in Adaptive Immunity

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
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A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

SuperHapten: a comprehensive database for small immunogenic compounds.

Stefan Günther¹, Dorothea Hempel, Mathias Dunkel

¹Institute of Molecular Biology and Bioinformatics, Charité-University Medicine Berlin, Arnimallee 22, 14195 Berlin, Germany. stefan.guenther@charite.de

Nucleic Acids Research

|November 9, 2006

Summary

This summary is machine-generated.

Researchers created SuperHapten, a comprehensive database of small molecules called haptens. This resource aids in understanding hapten properties and their role in allergies and disease.

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Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

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Published on: October 15, 2021

Area of Science:

Immunology and Bioinformatics
Chemical Biology

Background:

Haptens are small molecules that trigger immune responses when bound to larger molecules.
Hapten-induced allergies are common adverse drug reactions, yet their structural properties are poorly understood.
Haptens have applications in biosensors, immunomodulators, and vaccine development.

Purpose of the Study:

To develop a manually curated database, SuperHapten, integrating hapten information from diverse sources.
To provide a comprehensive resource for understanding the correlation between hapten structure and properties.
To facilitate research on hapten-induced allergies, autoimmune diseases, and related applications.

Main Methods:

Manual curation of literature and web resources to collect hapten data.
Integration of 2D/3D structures, physicochemical properties, and references for haptens.
Classification of haptens by origin (pesticides, drugs, natural compounds, etc.) and documentation of commercial availability and related antibodies.

Main Results:

The SuperHapten database currently contains approximately 7500 haptens and 25,000 synonyms.
Information on commercial availability for 6300 haptens and 450 related antibodies is included.
The database supports queries based on functional class, carrier protein, chemical scaffold, composition, and structural similarity.

Conclusions:

SuperHapten provides a valuable, integrated resource for hapten research.
The database enables experimental studies on hapten cross-reactivity and property-structure relationships.
Facilitates advancements in understanding hapten-induced immune responses and developing related technologies.