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Updated: Jul 19, 2026
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Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
Published on: April 1, 2022
Acute pancreatitis following naproxen intake
Gulbin Aygencel1, Betul Akbuga, Ayfer Keles
1Department of Emergency Medicine, Gazi University Faculty of Medicine, Besevler, Ankara, Turkey. gencel69@hotmail.com
Summary
Acute pancreatitis is a rare side effect of nonsteroidal anti-inflammatory drugs (NSAIDs). This case study details a young male who developed pancreatitis after a suicidal overdose of naproxen sodium, highlighting a rare adverse drug reaction.
Area of Science:
- Pharmacology
- Gastroenterology
- Toxicology
Background:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for pain and inflammation relief.
- While generally safe, NSAIDs can rarely cause serious adverse effects.
- Pancreatitis is an exceptionally uncommon complication associated with NSAID use.
Observation:
- A 20-year-old male presented with acute pancreatitis.
- The patient intentionally ingested a large quantity of naproxen sodium in a suicide attempt.
- This clinical presentation suggests a potential link between naproxen sodium and pancreatitis.
Findings:
- The case highlights acute pancreatitis as a rare adverse reaction to naproxen sodium.
- This event underscores the potential for severe gastrointestinal toxicity even with commonly prescribed medications.
- The mechanism linking NSAIDs to pancreatitis, though rare, warrants further investigation.
Implications:
- Clinicians should consider NSAIDs in the differential diagnosis of pancreatitis, especially in cases of overdose.
- This case emphasizes the importance of monitoring for rare adverse drug reactions.
- Further research into the specific mechanisms of NSAID-induced pancreatitis may inform clinical practice and patient safety guidelines.
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