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Related Concept Videos

Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Introduction to Sensory Receptors01:31

Introduction to Sensory Receptors

Sensory receptors are vital in our ability to perceive and interpret the world. Sensory receptors are specialized cells in the peripheral nervous system that respond to various stimuli and enable one to experience different sensations. Based on specific criteria, sensory receptors are classified into distinct types.
The first classification criterion is based on cell type, position, and function. Some receptor cells are neurons with free nerve endings, where their dendrites are embedded in the...
Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical, 7TM, or...
Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...

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Related Experiment Video

Updated: Jul 19, 2026

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology
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Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology

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Hot receptors in the brain.

Hendrik W Steenland1, Shanelle W Ko, Long-Jun Wu

  • 1Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Canada. h.steenland@utoronto.ca

Molecular Pain
|November 10, 2006
PubMed
Summary

Novel chronic pain treatments focus on the TRPV1 receptor (transient receptor potential vanilloid-1). Research highlights its role in supraspinal pain processing, particularly in the anterior cingulate cortex, and other brain functions.

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Chronic pain drug development utilizes two main strategies: targeting pain molecules or molecules involved in long-term plasticity.
  • The TRPV1 receptor is a key target for pain management, with most research focused on peripheral and spinal cord levels.

Purpose of the Study:

  • To review the expression and function of TRPV1 receptors in supraspinal brain structures.
  • To explore the potential role of TRPV1 in higher brain centers for pain processing.

Main Methods:

  • Literature review of research on TRPV1 receptors.
  • Analysis of studies investigating TRPV1 expression and function in supraspinal regions.

Main Results:

  • TRPV1 receptors are present in supraspinal structures, including the anterior cingulate cortex.

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Brain Membrane Fractionation: An Ex Vivo Approach to Assess Subsynaptic Protein Localization

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Last Updated: Jul 19, 2026

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Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp

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Brain Membrane Fractionation: An Ex Vivo Approach to Assess Subsynaptic Protein Localization

Published on: May 12, 2017

  • Evidence suggests TRPV1 receptors are involved in pain processing within higher brain areas.
  • Some brain regions utilize TRPV1 for functions unrelated to pain.

    • Conclusions:

    • The TRPV1 receptor is a potential therapeutic target for chronic pain, extending beyond the spinal cord and periphery.
    • Further research into supraspinal TRPV1 function may reveal novel treatment strategies for chronic pain.