Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Central nervous system vasculitis in children.

Susanne M Benseler1

  • 1Division of Pediatric Emergency Medicine and Rheumatology, Population Health Sciences Program, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada. susanne.benseler@sickkids.ca

Current Rheumatology Reports
|November 10, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From disability to daily life: functional status, quality of life and work productivity in real-world inflammatory arthritis.

Rheumatology (Oxford, England)·2026
Same author

Responsiveness of the EQ-5D-Y-5L Parent-Proxy Version Among Children with Juvenile Idiopathic Arthritis.

The patient·2026
Same author

Predicting recalcitrant hyperinflammatory disease course in children with Kawasaki disease and MIS-C.

Pediatric rheumatology online journal·2026
Same author

Fatigue in Inactive Auto-Inflammatory Diseases and Opportunities for Optimizing Clinical Care: A Single-Center Observational Study.

Journal of clinical medicine·2025
Same author

Development and Qualitative Evaluation of a Decision Support Tool for Withdrawal of Biologic Therapy in Nonsystemic Juvenile Idiopathic Arthritis.

MDM policy & practice·2025
Same author

Effect of Time to Start of Biologic Therapy on Treatment Response in Childhood Arthritis: Results From the UCAN CAN-DU Cohort.

Arthritis & rheumatology (Hoboken, N.J.)·2025

Central nervous system (CNS) vasculitis, an inflammatory brain condition, affects children and adults. This review focuses on childhood primary CNS vasculitis (cPACNS), covering diagnosis, presentation, and treatment.

Area of Science:

  • Neurology
  • Pediatric Neurology
  • Immunology

Background:

  • Central nervous system (CNS) vasculitis is a serious inflammatory condition affecting brain blood vessels in children and adults.
  • Primary or isolated CNS vasculitis of childhood (cPACNS) specifically involves inflammation limited to the brain and spinal cord.
  • Secondary CNS vasculitis can arise from infections, autoimmune diseases, or malignancies, and mimics include dissections and vasculopathies.

Purpose of the Study:

  • To review current data on CNS vasculitis in children.
  • To detail the clinical presentation, diagnostic methods, and treatment strategies for cPACNS.
  • To discuss outcomes and overlapping conditions associated with cPACNS.

Main Methods:

  • Literature review of recent data on pediatric CNS vasculitis.

Related Experiment Videos

  • Analysis of clinical presentation, laboratory tests, neuroimaging, and brain biopsy findings.
  • Synthesis of information on treatment strategies, outcomes, and related conditions.

    • Main Results:

    • CNS vasculitis is an increasingly recognized, potentially devastating disease.
    • Diagnosis in children and adults relies on the Calabrese criteria.
    • The review covers the spectrum of cPACNS, diagnostic modalities, and therapeutic approaches.

    Conclusions:

    • cPACNS requires careful diagnosis and management.
    • Understanding mimics and overlapping conditions is crucial for effective treatment.
    • This review provides a comprehensive overview for clinicians managing pediatric CNS vasculitis.