Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

614
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
614
Autoimmune Disorders01:29

Autoimmune Disorders

1.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.4K
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

286
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
286
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

443
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
443
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

445
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
445
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

264
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
264

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From disability to daily life: functional status, quality of life and work productivity in real-world inflammatory arthritis.

Rheumatology (Oxford, England)·2026
Same author

Emotional well-being at diagnosis may indicate future mental health risk in patients with juvenile idiopathic arthritis: data from the German inception cohort ICON.

RMD open·2026
Same author

[Autoinflammatory syndromes].

Deutsche medizinische Wochenschrift (1946)·2025
Same author

Long-term Effectiveness and Safety of Canakinumab in Patients with TRAPS: Analysis of the RELIANCE Non-Interventional Study.

Rheumatology and therapy·2025
Same author

Development and Qualitative Evaluation of a Decision Support Tool for Withdrawal of Biologic Therapy in Nonsystemic Juvenile Idiopathic Arthritis.

MDM policy & practice·2025
Same author

Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action.

The Journal of experimental medicine·2025

Related Experiment Video

Updated: Jan 9, 2026

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
04:24

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Published on: September 5, 2025

744

Fatigue in Inactive Auto-Inflammatory Diseases and Opportunities for Optimizing Clinical Care: A Single-Center

Yilmaz Satirer1,2, Özlem Satirer1,3, Susanne M Benseler3,4,5,6,7,8,9

  • 1Division of Pediatric Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tuebingen (arcT), University Hospital Tuebingen, 72076 Tuebingen, Germany.

Journal of Clinical Medicine
|December 11, 2025
PubMed
Summary

Debilitating fatigue persists in inactive auto-inflammatory diseases (AID). Depression is the primary driver of fatigue, necessitating integrated psychological and inflammatory care strategies for patients with AID.

Keywords:
CAPSCES-DFMFPedsQL-MFSautoinflammatory diseasesdepressionfatigue

More Related Videos

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.5K
The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
05:38

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

Published on: April 12, 2024

546

Related Experiment Videos

Last Updated: Jan 9, 2026

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
04:24

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Published on: September 5, 2025

744
Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.5K
The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
05:38

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

Published on: April 12, 2024

546

Area of Science:

  • Rheumatology
  • Immunology
  • Psychiatry

Background:

  • Auto-inflammatory diseases (AID) are a group of genetic disorders characterized by recurrent episodes of systemic inflammation.
  • Debilitating fatigue is a common and significant symptom in patients with AID, impacting quality of life.
  • Understanding fatigue phenotypes and risk factors in inactive AID is crucial for effective management.

Purpose of the Study:

  • To characterize fatigue in children and adults with inactive AID.
  • To identify disease-specific fatigue phenotypes.
  • To determine modifiable risk factors associated with fatigue in inactive AID.

Main Methods:

  • A single-center cohort study of 66 patients with inactive AID.
  • Fatigue was assessed using PedsQL-MFS and VAS; depression risk was evaluated with CES-D/CESD-R.
  • Non-parametric tests and multivariable regression were used to analyze data and identify risk factors.

Main Results:

  • Patients with cryopyrin-associated periodic syndromes (CAPS) reported higher cognitive fatigue.
  • Adults, patients with pathogenic variants, and those with longer disease duration experienced greater fatigue.
  • Depression was the strongest predictor of fatigue across all domains, even after adjusting for other factors.

Conclusions:

  • Fatigue remains a significant burden in inactive AID despite effective anti-inflammatory treatments.
  • Depression is the primary determinant of debilitating fatigue in this population.
  • Integrated screening for depression and tailored interventions addressing psychological and inflammatory aspects are essential for optimal patient care.