Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Volume-Stable Collagen Matrix With or Without Platelet-Rich Fibrin Impregnation for Multiple Gingival Recessions: A Randomized Clinical Trial.

Journal of periodontal research·2026
Same author

Dental microbrush tips: absence of acute cytotoxicity and NF-κB activation in human oral cells.

Odontology·2026
Same author

Myeloid A20 Regulates Periodontal Tissue Integrity and Temporomandibular Joint Structure.

Journal of periodontal research·2026
Same author

Transcriptomic characterization of platelet-rich fibrin-induced macrophage responses identifies U937 cells as a sensitive bioassay.

Frontiers in immunology·2026
Same author

Clinicians' Stress Levels During Soft Tissue Augmentation Using Autogenous Connective Tissue Grafts: A Pilot Study.

Clinical implant dentistry and related research·2026
Same author

RNA-Seq of Gingival Fibroblasts Grown on Collagen Membranes and Hyaluronic Acid.

Journal of functional biomaterials·2026

Related Experiment Video

Updated: Jul 19, 2026

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

Fracture healing in the elderly patient.

Reinhard Gruber1, Hannjörg Koch, Bruce A Doll

  • 1Department of Oral Surgery, Medical University of Vienna, Austria.

Experimental Gerontology
|November 10, 2006
PubMed
Summary

Fracture healing is more efficient in children than adults, but the elderly show impaired bone regeneration. Understanding age-related cellular and molecular changes is crucial for developing effective bone healing therapeutics.

More Related Videos

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

Related Experiment Videos

Last Updated: Jul 19, 2026

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

Area of Science:

  • Orthopedics
  • Gerontology
  • Regenerative Medicine

Background:

  • Clinical observations suggest age-related differences in fracture healing efficiency.
  • Fractures heal faster in children compared to adults, yet objective data is limited.
  • The cellular and molecular mechanisms of fracture healing in the elderly remain poorly understood.

Purpose of the Study:

  • To elucidate the biological basis of fracture healing in the geriatric skeleton.
  • To investigate age-related changes at cellular and molecular levels impacting bone regeneration.
  • To provide a foundation for understanding impaired bone healing in the elderly.

Main Methods:

  • Summarizing experimental studies on age-related changes in fracture healing.
  • Analyzing temporal, spatial, and cellular factors.
  • Examining signaling molecules and extracellular matrix in geriatric bone.

Main Results:

  • Fracture healing efficiency varies significantly across different age groups.
  • The elderly exhibit a compromised bone regeneration capacity compared to younger individuals.
  • Specific cellular and molecular alterations contribute to delayed healing in older patients.

Conclusions:

  • Understanding the pathophysiology of impaired fracture healing in the elderly is essential.
  • Knowledge of age-related changes can guide the development of targeted bone regeneration therapies.
  • Therapeutics for advanced-age fracture healing can be improved by addressing geriatric-specific biological factors.