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Updated: Jul 19, 2026
Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
Published on: September 12, 2011
Diffusion tensor imaging in children and adolescents: reproducibility, hemispheric, and age-related differences
David Bonekamp1, Lidia M Nagae, Mahaveer Degaonkar
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA.
Unlabelled:
We evaluated intra-rater, inter-rater, and between-scan reproducibility, hemispheric differences, and the effect of age on apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in healthy children (age range 5.5-19.1 years) examined with a clinical diffusion tensor imaging (DTI) protocol at 1.5 T, using a region of interest (ROI) methodology. Measures of reliability and precision were assessed in six ROIs using two different ROI shapes (polygonal and ellipsoidal).
Results:
Highly reproducible values of ADC and FA were obtained with the polygonal method on intra-rater (coefficients of variation
