Related Experiment Video

Updated: Jul 19, 2026

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
05:56

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

Cystic fibrosis related diabetes in an extremely young patient

Luis Casas1, Debbie R Berry, Kathy Logan

  • 1The University of Oklahoma Health Sciences Center, Department of Pediatrics, Oklahoma City, OK, 73104, USA. luis-casas@ouhsc.edu

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
|November 10, 2006
PubMed

Insights

Cystic fibrosis-related diabetes (CFRD) usually appears after age 10. This case study details a 2-year-old with cystic fibrosis successfully treated for early-onset CFRD with insulin.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Pulmonology

Background:

  • Cystic fibrosis (CF) is a genetic disorder affecting multiple organs, primarily the lungs and digestive system.
  • Cystic fibrosis-related diabetes (CFRD) is a common complication, typically diagnosed in patients over 10 years old.
  • Early detection and management of CFRD are crucial for improving patient outcomes.

Observation:

  • A male infant diagnosed with cystic fibrosis presented with symptoms suggestive of diabetes.
  • The patient developed diabetes at the unprecedented age of 2 years.
  • This presentation was consistent with an early-onset form of cystic fibrosis-related diabetes.

Findings:

  • The patient was diagnosed with cystic fibrosis-related diabetes at 2 years of age.
  • The early-onset diabetes was successfully managed with insulin therapy.
  • This case highlights the possibility of CFRD occurring significantly earlier than typically observed.

Implications:

  • This case challenges the conventional understanding of the typical age of onset for CFRD.
  • It underscores the importance of vigilant monitoring for diabetes in very young children with cystic fibrosis.
  • Further research may be needed to understand the mechanisms behind early-onset CFRD and optimize treatment strategies.

More Related Videos

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells06:27

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells

Published on: May 6, 2013

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-1906:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

Related Concept Videos

Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic sinusitis...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...