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Updated: Jul 19, 2026

Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis

Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis

Published on: July 6, 2022

Pathologic characteristics of the torn human meniscus.

Mena Mesiha¹, David Zurakowski, Jamil Soriano

¹Department of Orthopaedic Surgery, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

The American Journal of Sports Medicine

|November 10, 2006

Summary

Older patients have less cellular meniscus tissue, increasing retear risk. Age, injury duration, and tear type impact meniscus health and repair outcomes.

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Last Updated: Jul 19, 2026

Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis

Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis

Published on: July 6, 2022

Area of Science:

Orthopedic surgery
Biomedical engineering
Tissue engineering

Background:

Acellular meniscus tissue is prone to degeneration and retear.
Predicting low cellularity in torn menisci can identify patients at higher risk for surgical repair failure.

Purpose of the Study:

To identify patient factors predicting meniscus tissue cellularity.
To inform surgical decisions for meniscus tears.

Main Methods:

Descriptive laboratory study.
Gross and histologic evaluation of 44 patient and 10 control menisci.

Main Results:

Patient age, time since injury, and tear type significantly affected meniscus pathology.
Patients over 40 had lower cellularity (P < .01).
Increased time since injury correlated with DNA fragmentation and adjacent cartilage degeneration (Outerbridge II). Degenerative and radial tears showed worse histologic scores.

Conclusions:

Meniscus cellularity is significantly reduced in patients over 40.
Decreased cellularity in older patients may increase vulnerability to degeneration and retear post-repair.
Further research is needed to correlate histologic findings with clinical outcomes in meniscus repair.