Related Experiment Video
Updated: Jul 18, 2026
Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging
Published on: June 7, 2020
Bone and lung metastases from intracranial meningioma
Alessandra Fabi1, Carmen Nuzzo, Antonello Vidiri
1Division of Medical Oncology A, Regina Elena National Cancer Institute, via Elio Chianesi 53, 00144 Rome, Italy. alessandra.fabi@virgilio.it
Abstract:
Fifteen percent of intracranial tumors are represented by meningiomas. Meningioma is usually a benign neoplasm; malignant histology is rare and represents about 2-10% with a 43% incidence of metastasis. The most frequent site of metastasis is the lung and rare are other sites. There are no definitive criteria to predict the recurrence or metastases of meningioma and histological grading, according to WHO criteria, is the most important predictor of malignancy. A rare case of a woman with a relapse of intracranial meningioma in the right frontal lobe who subsequently developed simultaneous bone and intrapulmonary metastases is reported. According to these sites of metastases, it is suggested that in patients with a history of relapsed meningioma, a total body CT scan should be performed in order to investigate other possible sites of disease.
Insights
Meningiomas, typically benign intracranial tumors, can rarely metastasize. This case highlights simultaneous bone and lung metastases from a relapsed meningioma, suggesting whole-body CT scans for monitoring.
Area of Science:
- Neuro-oncology
- Pathology
- Radiology
Background:
- Meningiomas account for 15% of intracranial tumors, usually benign.
- Malignant histology is rare (2-10%), with a 43% metastasis rate, most commonly to the lungs.
- Predicting meningioma recurrence or metastasis lacks definitive criteria; WHO histological grading is key.
Observation:
- A rare case of a woman with relapsed intracranial meningioma.
- The patient developed simultaneous bone and intrapulmonary metastases.
- Metastases occurred in unusual sites beyond the typical lung involvement.
Findings:
- Histological grading is the primary predictor of meningioma malignancy.
- This case demonstrates simultaneous bone and lung metastases from a relapsed meningioma.
- The rarity of these specific metastatic sites underscores the unpredictable nature of the disease.
Implications:
- Consider total body CT scans for patients with relapsed meningioma.
- Investigate for diverse metastatic sites in recurrent meningioma cases.
- Enhanced surveillance may improve detection of disseminated meningioma disease.
More Related Videos
Related Concept Videos
01:31Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
01:27Cryptococcal Meningitis