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Laser assisted hatching in good prognosis patients undergoing in vitro fertilization-embryo transfer: a randomized
Arthur W Sagoskin1, Michael J Levy, Michael J Tucker
1Shady Grove Fertility Reproductive Science Center, Rockville, Maryland 20850, USA.
Objective:
To evaluate whether assisted hatching improves clinical outcomes of embryo transfers to good prognosis patients, defined as patients < or =39 years with normal follicle-stimulating hormone (FSH) and E(2) levels, no more than one previous unsuccessful cycle of in vitro fertilization (IVF)-embryo transfer, and good embryo quality.
Design:
Prospective randomized controlled trial.
Setting:
Private assisted reproductive technology (ART) center.
Patient(S):
One hundred ninety-nine good prognosis patients undergoing IVF-embryo transfer.
Intervention(S):
In vitro fertilization followed by embryo transfer on day 3 after oocyte retrieval with or without assisted hatching using a 1,480-nm wavelength infrared laser.
Main Outcome Measure(S):
Clinical intrauterine pregnancy, spontaneous pregnancy loss, and live birth.
Result(S):
Rates of clinical intrauterine pregnancy with fetal cardiac activity (53% vs. 54% per cycle), spontaneous pregnancy loss (13% vs. 16% per pregnancy), and live birth (47% vs. 46% per cycle) were very similar between treatment cycles with laser-assisted hatching and control cycles in which embryos were transferred without assisted hatching. There were no significant differences between treatment and control groups in any measured clinical outcome parameters.
Conclusion(S):
Assisted hatching does not improve clinical outcomes among good prognosis patients.
