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Experimental assessment of simulated moving bed and varicol processes using a single-column setup
Rui C R Rodrigues1, João M M Araújo, Mário F J Eusébio
1Requimte/CQFB, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.
Journal of Chromatography. A
|November 11, 2006
Summary
This study introduces a single-column system that accurately mimics multicolumn chromatography. It uses real-time monitoring and feedback control to achieve steady periodic behavior efficiently, minimizing resource consumption.
Area of Science:
- Chromatography
- Chemical Engineering
- Separation Science
Background:
- Countercurrent multicolumn chromatography (CMC) is a powerful separation technique.
- Reproducing its steady periodic behavior experimentally can be complex and resource-intensive.
Purpose of the Study:
- To develop a novel single-column setup that experimentally replicates the steady periodic behavior of simulated CMC.
- To reduce the time, mobile phase, and solute consumption required to achieve periodic operation.
Main Methods:
- Utilized a single-column system with online effluent monitoring.
- Implemented a feedback control loop using a node balance and a multi-pump configuration with time delay.
- Demonstrated feasibility using linear separation of two nucleosides with varying column configurations and port switching strategies.
- Employed a model-based startup procedure to attain the periodic state rapidly.
Main Results:
- Successfully reproduced the steady periodic behavior of CMC in a single-column setup.
- Achieved the periodic state in just one or two cycles by optimizing switching intervals and using a model-based startup.
- Significantly minimized mobile phase and solute consumption compared to traditional methods.
- Validated the system's performance across different column configurations and synchronous/asynchronous port switching.
Conclusions:
- The proposed single-column system offers an economic and efficient method for experimentally validating CMC operating conditions and cycle policies.
- This approach facilitates the optimization of separation performance for new multicolumn chromatographic processes.
- It provides a practical platform for testing and developing advanced chromatographic separation strategies.
